108 Deciphering the immune mechanism of autoreactive B cells in pemphigus

Redemption of autoreactive B cells.

Autoreactive antibodies can be pathogenic in a myriad of diseases. Consequently, the adaptive immune system actively removes or inactivates self-reactive B cells, while promoting the survival of B cells that recognize exogenous antigens, including microbial pathogens (1, 2). These physiological mechanisms of immune tolerance are often defective in autoimmune diseases (3, 4), and much effort is ...

Genetics of autoreactive B cells.

It is now well-accepted that autoimmune diseases develop as a result of interactions between a complex genetic basis and environmental triggers. Autoreactive B cells play a major role in many autoimmune diseases, by secreting autoantibodies or cytokines and/or presenting auto-antigens to T cells. Studies performed with human patients and murine models have accumulated evidence that B-cell autor...

Patients B Cell Repertoire in Pemphigus Vulgaris Dissecting the Anti-Desmoglein Autoreactive

26 Natural Activation of Autoreactive B Cells

Autoreact ive, immunocompe ten t B lymphocytes in peripheral lymphoid organs have long been considered "abnormal," as it was believed that such "forbidden clones" were normally deleted or inactivated in mature reper toi res (1-3). In fact, for the last 10 years autoreact ive B cells were shown to exist in available reper toi res by the appearance o f autoantibodies in graft vs. host disease and...

Autoimmunity: Deletion of autoreactive B cells

Several powerful mechanisms exist to prevent self-reactive B cells from maturing to secrete potentially destructive autoantibodies. These mechanisms act in addition to the removal of self-reactive helper T cells.